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US ponders testing 3-person fertilization technique on humans

Published time: February 26, 2014 11:03
Reuters / Shannon Stapleton

Reuters / Shannon Stapleton

Federal health regulators have been arguing the pros and cons of a controversial new fertilization method that would see babies created from the DNA of three people in an attempt to avoid possible genetic diseases.

A two-day hearing on the issue, initiated by the Food and Drug Administration (FDA), has been prompted by a successful testing of the technique on animals at the Oregon Health & Science University in Portland.

Group of researches, headed by Dr. Shoukhrat Mitalipov, used the method of DNA replacement to produce five healthy monkeys. Now the scientists say they are ready to test it on an initial sample of women at risk of passing on with genetic health conditions to their children, including blindness, diabetes, heart failure and epilepsy.

"We want to replace these mutated genes, which by nature have become pathogenic to humans," said Dr. Shoukhrat Mitalipov, AP reported. "We're reversing them back to normal, so I don't understand why you would be opposing that."

The opposition to the experiment has been strong, however. Critics argue that genetically modified embryos are unethical as they could be a step toward “designer babies,” meaning some parents would be willing to not just get rid of a defective trait, but customize their child’s appearance or intelligence.

At this stage, however, the FDA panel is examining technical, rather than ethical issues regarding the procedure. A number of experts argued that there’s still not enough evidence on the safety of the so-called “three-person fertilization” technique.

"The end of the experiment will come decades later," said Michigan State University's Keith Latham. "It's going to take us that long to figure out the health of the progeny produced from these procedures."

An estimated 1 in 4,000 US children inherit diseases due to mutations in mitochondrial DNA, which is only passed along by the mother. This type of DNA is located outside the nucleus of the cell, where the bulk of the traits-shaping genes are.

The technique, tested by Mitalipov, presupposes taking a healthy female donor egg and replacing its nucleus DNA with that of the baby’s mother, thus leaving behind her unhealthy mitochondrial DNA. The researcher argues it is only “gene correction”, not “gene modification”, since all of the major traits of the baby are in the nucleus, which stays intact.

On Wednesday, the FDA group is going to discuss the details of potential gene replacement in humans. So far, the first day of the FDA hearing shows that the US scientific community is still wary about testing the procedure on humans.

There’s overall great concern for the well-being of these kids,” Evan Y. Snyder, the panel’s chairman, said as cited by the Washington Post. “I think there was a sense of the committee that at this particular point in time, there was probably not enough data either in animals or in vitro to conclusively move on to human trials . . . without answering a few additional questions.

In more than 40 countries human genetic modifications that can be inherited are currently illegal.

The UK, however, has been considering softening its approach. It was drafting regulations last year which would allow the creation of human embryos using genetic material from three parents. The final version of the bill is expected to be debated and a voted in parliament this year.

Comments (8)


Ricardo Koch 26.02.2014 20:50

At 'Haris Dacic' time='26.02.2014

No my friend, eugenic is not comming! Eugenic was allways present in our world, allways hidden from the public perception and conscience. It was allways manifested in different ways, subtil ways. Or trough wars, famine and pandemia. The difference now is, now eugenic has not to hide anymore, because now we have absolutely no power to do something against it. Eugenic is the religion of the people who are the real rulers of our world, and we all will pay an terrible price for being weak and not capable to stop this monstruosity.


Ricardo Koch 26.02.2014 20:25

The real goal of this experiment is to destroy normal familys. They want create people with multiple progenitors, and than create laws for not discriminate those people. The new laws will degrade normal familys to an insignificant relict of the past. The next step will be to crate people in the lab, like my coworkers and me are doing with mice and rats. It sounds exacts like brave new world of Aldous Huxley.


82TransAm305 26.02.2014 18:05

X-gene imbound?

View all comments (8)
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